The Fourteen Holy Helpers are a group of saints venerated together in Roman Catholicism because their intercession is believed to be particularly effective, especially against various diseases. This group of Nothelfer ("helpers in need") originated in the 14th century at first in the Rhineland, largely as a result of the epidemic (probably of bubonic plague) that became known as the Black Death.

The fourteen saints are:

Agathius (Acacius) 8 May Against headache
Barbara 4 December Against fever and sudden death
Blaise (Blase, Blasius) 3 February Against illness of the throat and for protection of domestic animals
Catherine of Alexandria 25 November Against sudden death
Christopher (Christophorus) 25 July Against bubonic plague and dangers while traveling
Cyriacus 8 August Against temptation on the death-bed
Denis (Dionysius) 9 October Against headache
Erasmus (Elmo) 2 June Against intestinal ailments
Eustace (Eustachius, Eustathius) 20 September Against family discord
George (Georgius) 23 April For the health of domestic animals
Giles (Aegidius) 1 September Against plague, for a good confession, and for cripples, beggars and blacksmiths
Margaret of Antioch 20 July During childbirth, and escape from devils
Pantaleon (Panteleimon) 27 July For physicians, and against cancer and tuberculosis
Vitus (Guy) 15 June Against epilepsy, lightning and for protection of domestic animals