Isabella I was Queen of Castille. She was married to Ferdinand II of Aragon. Their marriage became the basis for the political unification of Spain under their grandson, Holy Roman Emperor Charles V. After a struggle to claim her right to the throne, she reorganized the governmental system, brought the crime rate to the lowest it had been in years, and unburdened the kingdom of the enormous debt her brother had left behind. Her reforms and those she made with her husband had an influence that extended well beyond the borders of their united kingdoms. Isabella and Ferdinand are known for completing the Reconquista, ordering conversion or exile of their Muslim and Jewish subjects in the Spanish Inquisition, and for supporting and financing Christopher Columbus's 1492 voyage that led to the opening of the New World and to the establishment of Spain as the first global power who dominated Europe and much of the world for more than a century. Isabella was granted the title Servant of God by the Catholic Church in 1974. The last thing that Isabella would do for others in her time was to break up another battle started by her son Affonso, the king at that point in time. Saint Isabella would pass away in the year 1336 on July 4th, due to a high fever. She was canonized a saint by Pope Urban VIII in 1625.